INTUNIV Attention Defict Hyperactivity Disorder
Shire pharmaceuticals has announced the release of a new medication for Attention Deficit Hyperactivity Disorder (ADHD). They have received FDA approval to market and sell INTUIV which is a long acting form of the medication guanfacine. Guanfacine is a medication that is used to treat high blood pressure but has long been used as a third or fourth line treatment for ADHD when stimulants, Strattera, or imipramine were unsuccessful or could not be tolerated or safely used. It has a chemical cousin, clonidine, which also has been used. Now guanfacine has been approved as a first line treatment.
Guanfacine has been approved for the use in children and adolescents ages 6 - 17. It is thought to work by affecting norepinephrine receptors in the prefrontal cortex, an area thought to be implicated in ADHD. Gunfacine is not a controlled substance, is not a stimulant, and has no abuse potential. Like many medications it has it's potential drawbacks as well. Common side effects are sedation, headaches, fatigue, upper abdominal pain and small changes in heart rate and blood pressure. In some patients it can cause a potentially dangerous drop in blood pressure and heart rate leading to fainting episodes. It should not be mixed with any othrt medication that can lower the blood pressure or heart rate.
Having another option for ADHD, particularly one that is not abusable is welcome. It is good to have another first line treatment. It does bring up the point I have made before about the need for caution in using any of the ADHD medications as they all have some effects on the cardiovascular system. It is my belief that all patients who are going to take these medications should have a prescreening electrocardiogram to help rule out any underlying heart disease. Not everyone agree with me about this. The American Heart Association does but the pediatric and pediactric psychiatry organizations have not yet adopted this viewpoint. I hope they will.
Thought for the day
All medical treatments have risks as well as benefits.
Guanfacine has been approved for the use in children and adolescents ages 6 - 17. It is thought to work by affecting norepinephrine receptors in the prefrontal cortex, an area thought to be implicated in ADHD. Gunfacine is not a controlled substance, is not a stimulant, and has no abuse potential. Like many medications it has it's potential drawbacks as well. Common side effects are sedation, headaches, fatigue, upper abdominal pain and small changes in heart rate and blood pressure. In some patients it can cause a potentially dangerous drop in blood pressure and heart rate leading to fainting episodes. It should not be mixed with any othrt medication that can lower the blood pressure or heart rate.
Having another option for ADHD, particularly one that is not abusable is welcome. It is good to have another first line treatment. It does bring up the point I have made before about the need for caution in using any of the ADHD medications as they all have some effects on the cardiovascular system. It is my belief that all patients who are going to take these medications should have a prescreening electrocardiogram to help rule out any underlying heart disease. Not everyone agree with me about this. The American Heart Association does but the pediatric and pediactric psychiatry organizations have not yet adopted this viewpoint. I hope they will.
Thought for the day
All medical treatments have risks as well as benefits.
Labels: ADHD, Daily-Musings, Electroconvulsive-Therapy
14 Comments:
any information on this medicine "Intuniv" for ADHD with Bipolar disorder?
I haven't seen any information on Intuniv for patient's who have both ADHD and Bipolar Disorder. There has been no problem that I am aware of however with the short acting guanfacine which is the active ingredient in Intuniv.
To any Patient or Medical Professional,
Does anyone have any opinion about, or know of any such an opinion stated or written by a health care provider, or patient, the direct or indirect use of ECT with ADHD (in all liklihood this will occur in cases of depression with ADHD and, so, the effect of the ECT treatments on the ADHD might or might not be considered "indirect", or "ad added bonus", by those involved. My cognitive therapist / psychiatrist expects that my ECT treatments should, in addition to their other benefits, lessen the strength of any distorted beliefs I have, and, therefore, also lessen the strength of any resulting maladaptive behaviors, or resulting obstacles to any adaptive behaviors. He also believes that trying to lessen the strength of such madadaptive beliefs and behaviors could very well even be worth have me on to a series of bilateral treatments as (i) these ADHD maladaptive beliefs, schemas, and resulting behaviors, or behavior challenges, are the primary source of my remaining negative feelings about myself. While the last statement is true, given that I find no support on this internet or any other internet site, nor in any ECT or even any TCM book, and given that my ECT physician is concerned at least enough about the increased memory impairment risk from bilateral ECT to work to avoid having to use any bilateral treatments, I am not sure that an attempt to treat ADHD symptomology with ECT is a good enough reason to try a series of, for example, three bilateral treatments.
I can't give you direct medical advice but I can tell you that the standard of treatment is unilateral ECT unless it is ineffective for an individual. I wish you well
When is the best time of day to take "intuniv"?
Sorry it has taken me awhile to get back to you. I have had no experience in prescribing Intuniv so I don't know the answer to your question. The PDR doesn't say except take once per day. I would think the time to take it would be the morning like other long acting ADHD medications unless someone had sedation from it. It should not be taken with a high fat meal however.
How long does the "effects" of intuniv last? Ex: 8 hrs, 12hrs, 24hrs? I'm concerned about my 12 year old - I dont want him sleepy in school and should intuniv make him sleepy, I'm thinking the best time to give it to him would be at night, with the idea, it will still help him while in school the next day for 7 hours.
The peak plasma concentration of Intuniv is 5 hours after the medication is taken. The elimination half life (when half of the medication has been eliminated from the body) is 18-22 hours. It seems like the best time to give the medication would be in the morning unless it does make him sleepy.
has anyone taken or given this med at night and get same results as if in the morning?
I wish I knew the answer to that. Assuming a 10:00 PM bedtime the peak plasma level would be at 3:00 AM and half of the medication would be eliminated by noon so it would seem that the AM is the best time to give the medication.
my son has been very sleepy the last two days, he actually fell asleep at school and when he got home he went to sleep at about 6:00pm and slept until 6:30 the next morning. is this normal with the medication?
Intuiv has worked for our child but a possible side effect may be nightmares or hallucinating.
Sleepiness has been one of the side effects of both clonidine and the standard preparation of guanfacine (extended release guanfacine is Intuniv). If this side effect doesn't improve quickly the another medication for ADHD should be considered.
This side effect is good to know about. I hope that stops so your child can continue the medication. It is another reminder that these medications we use for ADHD affect the brain and we have to be watchful for any neuropsychiatric side effects like you describe.
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